2-氨基-4-苯基-5-噻唑甲酸乙酯合成路线 （共 10 条）
参考文献
Ladouceur, Gaetan H.; Bullock, William H.; Magnuson, Steven R.; O'Connor, Stephen J.; Smith, Roger A.; Shen, Quanrong; Liu, Qingjie; Su, Ning; Velthuisen, Emil J.; Campbell, Ann-Marie; Ehrlich, Paul P.
Patent: US2003/78258 A1, 2003 ;
反应条件
in ethanol Heating / reflux;
参考文献
Ladouceur, Gaetan H.; Schoen, William R.; Burke, Michael J.
Patent: US2003/195352 A1, 2003 ;
Location in patent: Page/Page column 35 ;
反应条件
iodine; copper(II) oxide in ethanol T=78°C;
参考文献
Tetrahedron, , vol. 68, # 1 p. 173 - 178
反应条件
N-bromosuccinmide; xanthan sulfuric acid T=20°C; 0.3 h;
参考文献
Kuarm, Bowroju S.; Madhav, Janganati V.; Rajitha, Bhargavi
Letters in Organic Chemistry, 2011 , vol. 8, # 8 p. 549 - 553
反应条件
thiourea in ethyl acetate; acetonitrile
参考文献
DuPont Pharmaceuticals Company
Patent: US5998424 A1, 1999 ;
US 5998424 A
反应条件
1-methyl-1H-imidazole in water; isopropyl alcohol T=20°C; 2 h;
参考文献
Meshram; Thakur, Pramod B.; Madhu Babu; Bangade, Vikas M.
Tetrahedron Letters, 2012 , vol. 53, # 39 p. 5265 - 5269
参考文献
Journal of the Chemical Society, , p. 1656,1658
反应条件
1: With sodium hydroxide in ethanol; water T=20°C; 72 h; 2: With hydrogenchloride in water
参考文献
Aventis Pharma S.A.
Patent: US2005/14765 A1, 2005 ;
Location in patent: Page/Page column 17 ;
反应条件
hydrazine in methanol
50 h; Heating / reflux;
参考文献
H. Lundbeck A/S
Patent: WO2006/32273 A1, 2006 ;
Location in patent: Page/Page column 37 ;
WO 2006/032273 A1
反应条件
1.1: sulfuric acid; sodium nitrite / water / 0 °C
1.2: 1 h / 0 - 5 °C
2.1: sodium hydroxide / ethanol / 6 h / |Reflux
View Scheme
参考文献
Nagashima, Shinya; Matsushima, Yuji; Hamaguchi, Hisao; Nagata, Hiroshi; Kontani, Toru; Moritomo, Ayako; Koshika, Tadatsura; Takeuchi, Makoto
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 13 p. 3478 - 3487
