4-(2,3-二甲氧基苯基)丁酸合成路线 （共 11 条）
反应条件
sodium hydroxide in methanol
参考文献
Denny, William Alexander; Hutchings, Richard H; Johnson, Douglas S; Kaltenbronn, James Stanely; Lee, Ho Huat; Leonard, Daniele Marie; Milbank, Jared Bruce John; Repine, Joseph Thomas; Rewcastle, Gordon William; White, Andrew David
Patent: US2004/44057 A1, 2004 ;
反应条件
hydrogen; palladium on activated charcoal in acetic acid
参考文献
Beetz, Tom; Meuleman, Dick G.; Wieringa, Joop H.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 714 - 719
反应条件
1: NaH, Me2SO / tetrahydrofuran / 5 h / 5 °C
2: 57.6 g / H2 / 5percent Pd/C / acetic acid
View Scheme
参考文献
Beetz, Tom; Meuleman, Dick G.; Wieringa, Joop H.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 714 - 719
反应条件
hydrogen; acetic acid; palladium on activated charcoal in ethanol
Ambient temperature;
参考文献
Cooper, Christopher B.; Blair, Kyle T.; Jones, Christopher S.; Minich, Martha L.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1747 - 1752
反应条件
1: piperidine / pyridine / 50 °C
2: H2, AcOH / Pd/C / ethanol / Ambient temperature
View Scheme
参考文献
Cooper, Christopher B.; Blair, Kyle T.; Jones, Christopher S.; Minich, Martha L.
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1747 - 1752
反应条件
1: 85 percent / PPh3, CCl4 / Heating
2: 1.) Bu3N, Pd(OAc)2, 2.) H2 / 2.) 10percent Pd/C / 1.) 100 deg C, 2.) MeOH, 50 psi
3: 6 N aq. KOH / ethanol / 2 h / Heating
View Scheme
参考文献
Kumar, Punit
Organic Preparations and Procedures International, 1997 , vol. 29, # 4 p. 477 - 480
反应条件
1: 1.) Bu3N, Pd(OAc)2, 2.) H2 / 2.) 10percent Pd/C / 1.) 100 deg C, 2.) MeOH, 50 psi
2: 6 N aq. KOH / ethanol / 2 h / Heating
View Scheme
参考文献
Kumar, Punit
Organic Preparations and Procedures International, 1997 , vol. 29, # 4 p. 477 - 480
反应条件
potassium hydroxide in ethanol
2 h; Heating;
参考文献
Kumar, Punit
Organic Preparations and Procedures International, 1997 , vol. 29, # 4 p. 477 - 480
反应条件
polyphosphoric acid
T=60°C; Inert atmosphere;
参考文献
Bonner, Lisa A.; Chemel, Benjamin R.; Watts, Val J.; Nichols, David E.
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 18 p. 6763 - 6770
反应条件
1: PPA / 0.5 h / 60 °C / Inert atmosphere
2: boron trifluoride diethyl etherate / toluene / 3 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Bonner, Lisa A.; Laban, Uros; Chemel, Benjamin R.; Juncosa, Jose I.; Lill, Markus A.; Watts, Val J.; Nichols, David E.
ChemMedChem, 2011 , vol. 6, # 6 p. 1024 - 1040
