5-氨基-2-氯苯甲酸乙酯合成路线 (共 4 条)
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / tetrahydrofuran / 15 h 2: methanol; lithium borohydride / tetrahydrofuran; diethyl ether / 2 h 3: Dess-Martin periodane / dichloromethane / 0.5 h View Scheme
参考文献
AMGEN INC.; ASHTON, Kate; BARTBERGER, Michael D.; BOURBEAU, Matthew Paul; CROGHAN, Michael D.; FOTSCH, Christopher H.; HUNGATE, Randall W.; KONG, Ke; NISHIMURA, Nobuko; NORMAN, Mark H.; PENNINGTON, Lewis D.; REICHELT, Andreas; SIEGMUND, Aaron C.; TADESSE, Seifu; ST. JEAN, David Jr; YANG, Kevin C.; YAO, Guomin
Patent: WO2013/173382 A1, 2013 ;
反应条件
tin(ll) chloride in ethanol
T=70°C; 0.5 h;
参考文献
Bellamy; Ou
Tetrahedron Letters, 1984 , vol. 25, # 8 p. 839 - 842
反应条件
thionyl chloride
T=0°C; 3 h; Reflux;
参考文献
Deng, Jing; Feng, Enguang; Ma, Sheng; Zhang, Yan; Liu, Xiaofeng; Li, Honglin; Huang, Huang; Zhu, Jin; Zhu, Weiliang; Shen, Xu; Miao, Liyan; Liu, Hong; Jiang, Hualiang; Li, Jian
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4508 - 4522
反应条件
1: thionyl chloride / 0 °C / |Reflux
2: SnCl2·2H2O; hydrogenchloride / ethanol / 24 h / 20 °C
View Scheme
参考文献
Lori, Franco; Chafouleas, James; De Forni, Davide; Solinas, Antonio; Varga, Zoltán; Greff, Zoltán; Örfi, László; Kéri, György
Patent: US2014/57911 A1, 2014 ;