1: 10 percent / aq. NH3, CuSO4 / 5 h / 130 °C 2: 95 percent / H2 / Raney-Ni / methanol / 1 h / Ambient temperature View Scheme

1: 44 percent / bromine, aq. NaOH / 1.) 0 deg C, 0.5 h, 2.) RT, 2 h 2: 79 percent / potassium carbonate / dimethylsulfoxide / 1 h / Heating 3: 45 percent / nitric acid, conc. sulfuric acid / 2 h / 60 - 65 °C 4: 63 percent / hydrazine hydrate / Pd/C / ethanol / 0.5 h / Heating View Scheme

1: 79 percent / potassium carbonate / dimethylsulfoxide / 1 h / Heating 2: 45 percent / nitric acid, conc. sulfuric acid / 2 h / 60 - 65 °C 3: 63 percent / hydrazine hydrate / Pd/C / ethanol / 0.5 h / Heating View Scheme

1: 45 percent / nitric acid, conc. sulfuric acid / 2 h / 60 - 65 °C 2: 63 percent / hydrazine hydrate / Pd/C / ethanol / 0.5 h / Heating View Scheme

1: 70 percent / NH2OH*HCl 2: pyridine 3: 75 percent 4: 73 percent / H2 / 5percent Pd/C / 3040 Torr / Ambient temperature 5: 67 percent / aq. NaOH / 1 h / 65 °C View Scheme

1: pyridine 2: 75 percent 3: 73 percent / H2 / 5percent Pd/C / 3040 Torr / Ambient temperature 4: 67 percent / aq. NaOH / 1 h / 65 °C View Scheme

1: 73 percent / H2 / 5percent Pd/C / 3040 Torr / Ambient temperature 2: 67 percent / aq. NaOH / 1 h / 65 °C View Scheme

1: 75 percent 2: 73 percent / H2 / 5percent Pd/C / 3040 Torr / Ambient temperature 3: 67 percent / aq. NaOH / 1 h / 65 °C View Scheme

1.1: tetrahydrofuran 2.1: n-butyllithium / tetrahydrofuran / 1 h / -70 - -25 °C / Large scale reaction 2.2: 1 h / -70 - -65 °C 3.1: hydrogenchloride / methanol; water / 4 h / 45 °C / Large scale reaction 4.1: iron sulphate heptahydrate; sodium 3-nitrobenzene sulfonate; sulfuric acid; boric acid / water / 6 h / 135 - 145 °C / Large scale reaction 5.1: lithium hydroxide hydrate / N,N-dimethyl-formamide / 24 h / 120 - 130 °C / Large scale reaction 6.1: sodium periodate / methanol; water / 16 h / 30 - 40 °C / Large scale reaction 7.1: lithium chloride / N,N-dimethyl-formamide / 0.5 h / 110 - 120 °C / Large scale reaction View Scheme

1.1: tetrahydrofuran 2.1: n-butyllithium / tetrahydrofuran / 1 h / -70 - -25 °C / Large scale reaction 2.2: 1 h / -70 - -65 °C View Scheme