3-羟基-3-(三氟甲基)吡咯烷-1-羧酸叔丁酯合成路线 (共 1 条)
反应条件
1: With tetrabutyl ammonium fluoride in tetrahydrofuran
T=0 - 20°C;
2: With water; ammonium chloride in tetrahydrofuran; water
0.25 h;
3: With tetrabutyl ammonium fluoride in tetrahydrofuran; water
T=20°C; 1 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/5295 A1, 2004 ;
Location in patent: Page 158-159 ;