N-Boc-4-(4-氯苯基)-4-哌啶羧酸合成路线 （共 4 条）
反应条件
1: With sodium hydroxide in tetrahydrofuran; water 18 h; 2: With hydrogenchloride; water in tetrahydrofuran
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; ASTRAZENECA AB
Patent: WO2006/136829 A2, 2006 ;
Location in patent: Page/Page column 121 ;
WO 2006/136829 A2
反应条件
sodium hydroxide in ethanol
参考文献
Luly, Jay R.; Nakasato, Yoshisuke; Ohshima, Etsuo; Harriman, Geraldine C.B.; Carson, Kenneth G.; Ghosh, Shomir; Elder, Amy M.; Mattia, Karen M.
Patent: US2005/70549 A1, 2005 ;
反应条件
1: 4-(4-chlorophenyl)-4-cyanopiperidine-1-carboxylic acid tert-butyl ester With hydrogenchloride; water 96 h; Heating / reflux; 2: With sodium hydroxide in water 3: di-tert-butyl dicarbonate in water 24 h;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2007/125321 A2, 2007 ;
Location in patent: Page/Page column 132 ;
WO 2007/125321 A2
反应条件
1: 4-(4-chlorophenyl)-4-cyanopiperidine-1-carboxylic acid tert-butyl ester With hydrogenchloride; water 96 h; Heating / reflux; 2: di-tert-butyl dicarbonate With sodium hydroxide in water 24 h;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2006/51290 A2, 2006 ;
Location in patent: Page/Page column 147 ;
WO 2006/051290 A2
