4-溴-2,3-二氟苯甲醛合成路线 （共 2 条）
反应条件
1: 2,3-difluoro-1,4-dibromobenzene With isopropylmagnesium chloride; lithium chloride in tetrahydrofuran
T=-35 - 40°C; 2 h;
2: N,N-dimethyl-formamide in tetrahydrofuran
T=-30 - 15°C; 3.5 h;
参考文献
Roche Palo Alto LLC
Patent: US2006/25462 A1, 2006 ;
Location in patent: Page/Page column 11; 21 ;
反应条件
1: C6H2Br3F With i-PrMgBr*LiCl in tetrahydrofuran
T=-35 - 40°C; 2 h;
2: N,N-dimethyl-formamide in tetrahydrofuran
T=-30 - 15°C; 3.5 h;
参考文献
Roche Palo Alto LLC
Patent: US2008/45511 A1, 2008 ;
Location in patent: Page/Page column 23-24 ;
