(±)-E-5-[3-(二甲氨基)丙叉基]-10.11-二氢-5H-二苯并[a,d]环庚烯-10-醇合成路线 （共 6 条）
反应条件
sodium tetrahydroborate in methanol
1.5 h; Heating; Yield given;
参考文献
Lassen; Perregaard
1983 , vol. 37, # 4 B p. 335 - 340
反应条件
1: 3M HCl / 2 h / 80 °C
2: NaBH4 / methanol / 1.5 h / Heating
View Scheme
参考文献
Lassen; Perregaard
1983 , vol. 37, # 4 B p. 335 - 340
反应条件
1: AcOH, conc. HCl / 1.5 h / Heating
2: t-BuOK / toluene / 2 h / 85 °C
3: 3M HCl / 2 h / 80 °C
4: NaBH4 / methanol / 1.5 h / Heating
View Scheme
参考文献
Lassen; Perregaard
1983 , vol. 37, # 4 B p. 335 - 340
反应条件
1: t-BuOK / toluene / 2 h / 85 °C
2: 3M HCl / 2 h / 80 °C
3: NaBH4 / methanol / 1.5 h / Heating
View Scheme
参考文献
Lassen; Perregaard
1983 , vol. 37, # 4 B p. 335 - 340
反应条件
cDNA-expressed human cytochrome P450 (CYP) 2D6 enzyme in water
T=37°C; hydroxylation; pH=7.4; 0.25 h; Enzymatic reaction; Enzyme kinetics; Further Variations:Reagents;
参考文献
Olesen, Ole V.; Linnet, Kristian
Pharmacology, 1997 , vol. 55, # 5 p. 235 - 243
反应条件
glucose-6-phosphate dehydrogenase; Tris-HCl buffer; G6P; liver microsomes of Wistar rats; NADPH; magnesium chloride in water
T=37°C; Rate constantProduct distribution;
参考文献
Masubuchi, Yasuhiro; Iwasa, Takashi; Fujita, Shoichi; Suzuki, Tokuji; Horie, Toshiharu; Narimatsu, Shizuo
Journal of Pharmacy and Pharmacology, 1996 , vol. 48, # 9 p. 925 - 929
