(S)-(+)-3-(2,2-二甲基-1,3-二氧戊环-4-基)-反式-丙酸乙酯合成路线 （共 24 条）
反应条件
1: diisobutylaluminium hydride / dichloromethane / -78 °C 2: N-bromosuccinmide; triphenylphosphine / dichloromethane / 0 - 20 °C View Scheme
参考文献
Ellwood, Adam R.; Mortimer, Anne J. Price; Goodman, Jonathan M.; Porter, Michael J.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 43 p. 7530 - 7539
反应条件
1: HCl / ethanol / 2 h / 20 °C
2: hydrogen / Pd/C / ethanol / 20 °C
3: 6.16 g / imidazole; 4-(dimethylamino)pyridine / CH2Cl2
4: 98 percent / DIBAL-H / tetrahydrofuran; hexane / 1 h / -78 °C
View Scheme
参考文献
Smith III, Amos B.; Kim, Dae-Shik
Organic Letters, 2005 , vol. 7, # 15 p. 3247 - 3250
反应条件
1: lithium aluminium tetrahydride; AlCl3, aluminium chloride / diethyl ether / 1 h / 0 - 20 °C
2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.5 h / 0 - 20 °C
3: methanol; (S,S)-[CuCl(C10H6N3(phenyl)2C6H2(CH3)2C(CH3)3)]; sodium t-butanolate / diethyl ether / 16 h / -55 °C
4: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; diethyl ether; water / 1 h / -55 - 20 °C
View Scheme
参考文献
Park, Jin Kyoon; McQuade, D. Tyler
Angewandte Chemie - International Edition, 2012 , vol. 51, # 11 p. 2717 - 2721
反应条件
diisobutylaluminium hydride in diethyl ether; hexane
0.25 h;
参考文献
Aar, Marcel P. M. van; Thijs, Lambertus; Zwanenburg, Binne
Tetrahedron, 1995 , vol. 51, # 35 p. 9699 - 9712
