1.1: hydrogenchloride; water / acetone / 0.17 h / 20 °C / |Inert atmosphere 2.1: sodium tetrahydroborate / ethanol / 0 °C 3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C 4.1: bromine / dichloromethane / -78 °C 4.2: |Reflux 5.1: oxalyl dichloride / dichloromethane; dimethyl sulfoxide / 1 h / -78 °C / |Inert atmosphere 5.2: -78 °C / |Inert atmosphere; |Enzymatic reaction 6.1: tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate / toluene / 100 °C / |Inert atmosphere View Scheme