bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in tetrahydrofuran T=40°C; Sonogashira coupling; 24 h;

1: 42 percent / Et3N; PdCl2(PPh3)2; CuI / PPh3 / tetrahydrofuran / 24 h / 40 °C 2: 92 percent / n-Bu4NF / tetrahydrofuran / 16 h / 20 °C View Scheme