1-(4,6-二甲基-2-嘧啶基)乙酮合成路线 （共 6 条）
反应条件
hydrogenchloride in water; acetone
T=20°C; 16 h;
参考文献
SYNGENTA PARTICIPATIONS AG; TRAH, Stephan; ZAMBACH, Werner; STIERLI, Daniel; NEBEL, Kurt; BORTOLATO, Andrea
Patent: WO2012/62844 A1, 2012 ;
Location in patent: Page/Page column 117-118 ;
反应条件
(NH4)2S2O8; sulfuric acid; silver nitrate in water
T=50°C; 1.5 h;
参考文献
Sakamoto, Takao; Ono, Takayasu; Sakasai, Takeji; Yamanaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 1 p. 202 - 207
反应条件
sulfuric acid; water; mercuric sulphate in acetone
2 h; Heating;
参考文献
Sakamoto, Takao; Kondo, Yoshinori; Shiraiwa, Masafumi; Yamanaka, Hiroshi
Synthesis, 1984 , # 3 p. 245 - 247
反应条件
1.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 43 h / 100 °C
1.2: 1 h / 20 °C
2.1: hydrogenchloride / water; acetone / 16 h / 20 °C
View Scheme
参考文献
SYNGENTA PARTICIPATIONS AG; TRAH, Stephan; ZAMBACH, Werner; STIERLI, Daniel; NEBEL, Kurt; BORTOLATO, Andrea
Patent: WO2012/62844 A1, 2012 ;
反应条件
in benzene
0.166667 h; Ambient temperature;
参考文献
Yamamoto, Yutaka; Ouchi, Hidekazu; Tanaka, Takuo; Morita, Yasuo
Heterocycles, 1995 , vol. 41, # 6 p. 1275 - 1290
反应条件
hydrogenchloride
1)ether-benzene, reflux, 4 h, then ice; Yield given. Multistep reaction;
参考文献
Naumenko, I. I.; Mikhaleva, M. A.; Mamaev, V. P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1981 , vol. 17, # 7 p. 710 - 714
Khimiya Geterotsiklicheskikh Soedinenii, 1981 , # 7 p. 958 - 962
