1: With formic acid; palladium on activated charcoal in ethanol
Inert atmosphereHeating;
2: With sodium hydroxide in chloroform; water
pH=~ 12; Cooling with ice-water;
参考文献
TARGACEPT, INC.
Patent: WO2009/91561 A1, 2009 ;
Location in patent: Page/Page column 29-30 ;