2-环戊基肼羧酸 1,1-二甲基乙酯合成路线 （共 6 条）
反应条件
hydrogenchloride in tetrahydrofuran 0.166667 h; Heating; Yield given;
参考文献
Ghali, N. I.; Venton, D. L.; Hung, S. C.; Le Breton, G. C.
Journal of Organic Chemistry, 1981 , vol. 46, # 26 p. 5413 - 5414
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 1 h;
参考文献
Ranatunge, Ramani R.; Augustyniak, Michael; Bandarage, Upul K.; Earl, Richard A.; Ellis, James L.; Garvey, David S.; Janero, David R.; Letts, L. Gordon; Martino, Allison M.; Murty, Madhavi G.; Richardson, Stewart K.; Schroeder, Joseph D.; Shumway, Matthew J.; Tam, S. William; Trocha, A. Mark; Young, Delano V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 9 p. 2180 - 2193
反应条件
hydrogen; acetic acid; palladium/active carbon in methanol
P=2250.23 Torr; 5 h;
参考文献
KYOWA HAKKO KOGYO CO., LTD.
Patent: EP1637532 A1, 2006 ;
Location in patent: Page/Page column 14 ;
反应条件
1: With sodium cyanoborohydride; acetic acid in methanol
T=20°C;
2: With sodium hydroxide; water in methanol
T=0°C;
参考文献
GLAXO GROUP
Patent: EP1918284 A1, 2008 ;
Location in patent: Page/Page column 18 ;
EP 1918284 A1
反应条件
1: 100 percent / methanol / 2 h / 20 °C
2: sodium cyanoborohydride; aq. acetic acid / 2 h / 20 °C
View Scheme
参考文献
Ranatunge, Ramani R.; Augustyniak, Michael; Bandarage, Upul K.; Earl, Richard A.; Ellis, James L.; Garvey, David S.; Janero, David R.; Letts, L. Gordon; Martino, Allison M.; Murty, Madhavi G.; Richardson, Stewart K.; Schroeder, Joseph D.; Shumway, Matthew J.; Tam, S. William; Trocha, A. Mark; Young, Delano V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 9 p. 2180 - 2193
反应条件
1: 100 percent / methanol / 2 h / 20 °C
2: sodium cyanoborohydride; aq. acetic acid / 2 h / 20 °C
View Scheme
参考文献
Ranatunge, Ramani R.; Augustyniak, Michael; Bandarage, Upul K.; Earl, Richard A.; Ellis, James L.; Garvey, David S.; Janero, David R.; Letts, L. Gordon; Martino, Allison M.; Murty, Madhavi G.; Richardson, Stewart K.; Schroeder, Joseph D.; Shumway, Matthew J.; Tam, S. William; Trocha, A. Mark; Young, Delano V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 9 p. 2180 - 2193
