1: 93 percent / NaH, C2H5SH / dimethylformamide / 10 h / Heating 2: 60 percent / NaOEt / ethanol / 24 h / Heating View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11604118', constants.ctx, '0')">tetrakis(triphenylphosphine) palladium⁽⁰⁾</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />12&nbsp;h;&nbsp;&nbsp;Heating;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 1.) Cp₂TiCl₂, 2.) NBS / 1.) CH₂Cl₂, RT, 6 h, 2.) from -70 deg C to -78 deg C, 0.5 h<br />2: 95 percent / Pd(PPh₃)4 / tetrahydrofuran / 10 h / Heating<br />3: 85 percent / Br₂, NaOMe / CH₂Cl₂; methanol / 2 h / -78 - 20 &deg;C<br />4: 84 percent / Pd(PPh₃)4 / tetrahydrofuran / 12 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: diethyl ether / 2 h / Heating<br />2: H₂SO₄, AcOH / 0.33 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: NaOEt / ethanol / 4.17 h / Heating<br />2: diethyl ether / 2 h / Heating<br />3: H₂SO₄, AcOH / 0.33 h / Heating<br /> <br /> &nbsp;