反应条件
1: 85 percent / Et3N / CH2Cl2 / 2 h / 20 °C
2: 1.) t-butyllithium, 3.) 10percent KOH / 1.) ether, -78 deg C, 15 min, 2.) ether, -78 deg C, 1 h, hexane, reflux 3 h, 3.) CH3OH, reflux 4 h
3: 89 percent / Et3N / diethyl ether / 1 h / 0 - 35 °C
4: 96 percent / pyridine / 12 h / 0 °C
5: 55 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Heating
6: 86 percent / KOH / H2O; propan-2-ol / 0.5 h / 45 °C
View Scheme
参考文献
Gerdes, John M.; Mathis, Chester A.; Shulgin, Alexander T.
Tetrahedron Letters, 1988 , vol. 29, # 50 p. 6537 - 6540
