1: 2,2,4-trimethyl-4-octyl-[1,3]oxathiolan-5-one With sodium ethanolate in ethanol
T=20°C; 0.5 h;
2: acetyl chloride With triethylamine in dichloromethane
T=0°C; 0.666667 h;
参考文献
FASGEN LLC; THE JOHNS HOPKINS UNIVERSITY
Patent: WO2008/57585 A1, 2008 ;
Location in patent: Page/Page column 16 ;
triethylamine in dichloromethane
T=0°C; 0.666667 h;
参考文献
McFadden, Jill M.; Medghalchi, Susan M.; Thupari, Jagan N.; Pinn, Michael L.; Vadlamudi, Aravinda; Miller, Katherine I.; Kuhajda, Francis P.; Townsend, Craig A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 4 p. 946 - 961
1.1: LiHMDS / tetrahydrofuran / -78 °C
1.2: 81 percent / tetrahydrofuran / -78 °C
2.1: ethanol / 2 h / 20 °C
3.1: 725 mg / NEt3 / CH2Cl2 / 0.67 h / 0 °C
View Scheme
参考文献
McFadden, Jill M.; Medghalchi, Susan M.; Thupari, Jagan N.; Pinn, Michael L.; Vadlamudi, Aravinda; Miller, Katherine I.; Kuhajda, Francis P.; Townsend, Craig A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 4 p. 946 - 961
1.1: 73 percent / LiHMDS / tetrahydrofuran / -78 - -5 °C
2.1: NaH / dimethylformamide / -40 - 0 °C
2.2: 70 percent / dimethylformamide / 0 - 20 °C
3.1: 89 percent / trifluoroacetic acid / CH2Cl2 / 4 h / 20 °C
View Scheme
参考文献
McFadden, Jill M.; Medghalchi, Susan M.; Thupari, Jagan N.; Pinn, Michael L.; Vadlamudi, Aravinda; Miller, Katherine I.; Kuhajda, Francis P.; Townsend, Craig A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 4 p. 946 - 961
