1.1: 99 percent / H2; HCl / Pd/C / ethanol / 64.5 h / 20 °C / atmospheric pressure 2.1: carbonyldiimidazole / toluene / 2 h / 20 °C 2.2: triethylamine / toluene / 112 h / 20 °C 3.1: trifluoroacteic acid / toluene / 3 h / 20 °C View Scheme

hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol T=20°C; 64.5 h; atmospheric pressure;

{Pd2dba2*CHCl3}; (R)-1,1'-bis(diphenylphosphino)-2,2'-binapthyl; sodium t-butanolate in toluene T=80 - 85°C; 2.5 h;