1-(4-氯苯基)-2-(2-氯嘧啶-4-基)乙酮合成路线 （共 2 条）
反应条件
1: 2-chloro-4-methyl-pyrimidine With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene
T=-74°C; 3 h;
2: p-EtOC(O)C6H4Cl in tetrahydrofuran; n-heptane; ethylbenzene
T=-74 - 20°C; 21.5 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/5282 A1, 2004 ;
Location in patent: Page 36; 38 ;
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 16 h;
参考文献
Humphries, Paul S.; Do, Quyen-Quyen T.; Wilhite, David M.
Tetrahedron Letters, 2009 , vol. 50, # 21 p. 2552 - 2554
