3-环己基-3-氧代丙酸甲酯合成路线 （共 13 条）
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=-78°C;
参考文献
Taber,D.F.; Deker,P.B.; Gaul,M.D.
Journal of the American Chemical Society, 1987 , vol. 109, p. 7488
反应条件
1: 2,2-Dimethyl-[1,3]dioxane-4,6-dione; cyclohexane carboxylic acid chloride With pyridine in dichloromethane
T=20°C; 2 h;
2: methanol in dichloromethane
2 h; Further stages.;
参考文献
Teng, Xin; Keys, Heather; Jeevanandam, Arumugasamy; Porco Jr., John A.; Degterev, Alexei; Yuan, Junying; Cuny, Gregory D.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 24 p. 6836 - 6840
反应条件
1: oxalyl chloride / dimethylformamide; CH2Cl2 / 1.) 0 deg C, 2.) RT, 3 h
2: 87 percent / LDA / tetrahydrofuran / -78 °C
View Scheme
参考文献
Taber,D.F.; Deker,P.B.; Gaul,M.D.
Journal of the American Chemical Society, 1987 , vol. 109, p. 7488
参考文献
BIOTHERYX, INC.; MERCURIO, Frank; CHAN, Kyle, W.H.
Patent: WO2011/153197 A1, 2011 ;
Location in patent: Page/Page column 100 ;
反应条件
1: mono-methyl malonate potassium salt With magnesium chloride in tetrahydrofuran
T=65°C; 5 h; Inert atmosphere;
2: 1-cyclohexanecarbonyl-1H-imidazole in tetrahydrofuran
T=30°C; 24 h; Inert atmosphere;
参考文献
Allan, Kevin M.; Hong, Boram D.; Stoltz, Brian M.
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 23 p. 4960 - 4964
反应条件
2: sodium methylate
View Scheme
参考文献
Mousseron et al.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1955 , vol. 241, p. 602
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
反应条件
sodium hydride in toluene
Reflux;
参考文献
Zheng, Hong-Jie; Chen, Wen-Bing; Wu, Zhi-Jun; Deng, Jin-Gen; Lin, Wen-Qing; Yuan, Wei-Cheng; Zhang, Xiao-Mei
Chemistry - A European Journal, 2008 , vol. 14, # 32 p. 9864 - 9867
参考文献
Mousseron et al.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1955 , vol. 241, p. 602
反应条件
n-butyllithium; diisopropylamine
参考文献
Sum,P.-E.; Weiler,L.
Canadian Journal of Chemistry, 1977 , vol. 55, p. 996 - 1000
