6-羟基-3-苯基-2H-色烯-2-酮合成路线 （共 8 条）
反应条件
hydrogenchloride in methanol
T=100°C; 2 h;
参考文献
Kabeya, Luciana M.; de Marchi, Anderson A.; Kanashiro, Alexandre; Lopes, Norberto P.; da Silva, Carlos H.T.P.; Pupo, Monica T.; Lucisano-Valim, Yara M.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 3 p. 1516 - 1524
反应条件
(5aS,10bR)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride; triethylamine in ethyl acetate
T=80°C; 4 h; Inert atmosphereMolecular sieve;
参考文献
Jiang, Yuansong; Chen, Wanzhi; Lu, Weimin
Tetrahedron, 2013 , vol. 69, # 18 p. 3669 - 3676
反应条件
1: 30 percent / CH3CO2K / 3.5 h / 138 °C
2: 79 percent / aq. HCl / methanol / 2 h / 100 °C
View Scheme
参考文献
Kabeya, Luciana M.; de Marchi, Anderson A.; Kanashiro, Alexandre; Lopes, Norberto P.; da Silva, Carlos H.T.P.; Pupo, Monica T.; Lucisano-Valim, Yara M.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 3 p. 1516 - 1524
反应条件
1: 30 percent / CH3CO2K / 3.5 h / 138 °C
2: 79 percent / aq. HCl / methanol / 2 h / 100 °C
View Scheme
参考文献
Kabeya, Luciana M.; de Marchi, Anderson A.; Kanashiro, Alexandre; Lopes, Norberto P.; da Silva, Carlos H.T.P.; Pupo, Monica T.; Lucisano-Valim, Yara M.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 3 p. 1516 - 1524
反应条件
1.1: sodium hydride / dimethyl sulfoxide / 1 h / 0 °C / |Inert atmosphere
1.2: 3 h / 20 °C / |Inert atmosphere
2.1: hydrogenchloride / water; chloroform / 3 h / 20 °C / |Inert atmosphere
3.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / |Inert atmosphere
4.1: triethylamine; (5aS,10bR)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride / ethyl acetate / 4 h / 80 °C / |Inert atmosphere; |Molecular sieve
View Scheme
参考文献
Jiang, Yuansong; Chen, Wanzhi; Lu, Weimin
Tetrahedron, 2013 , vol. 69, # 18 p. 3669 - 3676
反应条件
1: hydrogenchloride / water; chloroform / 3 h / 20 °C / |Inert atmosphere
2: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / |Inert atmosphere
3: triethylamine; (5aS,10bR)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride / ethyl acetate / 4 h / 80 °C / |Inert atmosphere; |Molecular sieve
View Scheme
参考文献
Jiang, Yuansong; Chen, Wanzhi; Lu, Weimin
Tetrahedron, 2013 , vol. 69, # 18 p. 3669 - 3676
反应条件
1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C / |Inert atmosphere
2: triethylamine; (5aS,10bR)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride / ethyl acetate / 4 h / 80 °C / |Inert atmosphere; |Molecular sieve
View Scheme
参考文献
Jiang, Yuansong; Chen, Wanzhi; Lu, Weimin
Tetrahedron, 2013 , vol. 69, # 18 p. 3669 - 3676
反应条件
1: L-proline; N-chloro-succinimide / dichloromethane / 3 h / 0 - 20 °C / |Inert atmosphere
2: triethylamine; (5aS,10bR)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride / ethyl acetate / 4 h / 80 °C / |Inert atmosphere; |Molecular sieve
View Scheme
参考文献
Jiang, Yuansong; Chen, Wanzhi; Lu, Weimin
Tetrahedron, 2013 , vol. 69, # 18 p. 3669 - 3676
