3-氯-9H-噻吨-9-酮合成路线 （共 10 条）
反应条件
1: With sulfuric acid
T=100°C; 4 h;
2: in water
T=0°C; 0.5 h;
参考文献
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Patent: WO2006/60774 A2, 2006 ;
Location in patent: Page/Page column 74-75 ;
反应条件
Na2S*9H2O in N,N-dimethyl-formamide
T=60°C;
参考文献
Kobayashi, Kazuhiro; Komatsu, Toshihide; Nakagawa, Kazuhiro; Hara, Erika; Yuba, Shohei
Heterocycles, 2013 , vol. 87, # 12 p. 2577 - 2587
参考文献
Sanofi Winthrop, Inc.
Patent: US5665760 A1, 1997 ;
反应条件
1: KOH; Cu / 8 h / 120 °C
2: H2SO4 / 4 h / 100 °C
View Scheme
参考文献
Lory, Pedro M. J.; Agarkov, Anton; Gilbertson, Scott R.
Synlett, 2006 , # 18 p. 3045 - 3048
反应条件
sulfuric acid
T=0°C; 1 h;
参考文献
SANOFI-SYNTHELABO
Patent: EP1197491 A1, 2002 ;
Location in patent: Page 14 ;
反应条件
1: KOH; Cu / 8 h / 120 °C
2: H2SO4 / 4 h / 100 °C
View Scheme
参考文献
Lory, Pedro M. J.; Agarkov, Anton; Gilbertson, Scott R.
Synlett, 2006 , # 18 p. 3045 - 3048
反应条件
1: methanol. sodium methylate; copper-powder
2: concentrated sulfuric acid
View Scheme
参考文献
Mahishi et al.
Journal of the Karnatak University, 1957 , vol. 2, p. 50,57
反应条件
diethyl ether
anschliessend mit wss. Ammoniumchlorid-Loesung behandeln;
参考文献
Hoffmann-La Roche
Patent: DE1044103 , 1957 ;
反应条件
dihydrogen peroxide in acetic acid
T=90°C; 12.5 h;
参考文献
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM; MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Patent: WO2006/60774 A2, 2006 ;
Location in patent: Page/Page column 75 ;
反应条件
dihydrogen peroxide; acetic acid
T=90°C; Product distribution; Further Variations:ReagentsSolventsTemperatures;
参考文献
Lory, Pedro M. J.; Agarkov, Anton; Gilbertson, Scott R.
Synlett, 2006 , # 18 p. 3045 - 3048
