2-溴-4,5-二氟苯胺合成路线 （共 10 条）
反应条件
bromine; potassium carbonate in dichloromethane T=-15°C; 0.5 h;
参考文献
Ishikawa; Uno; Miyamoto; Ueda; Tamaoka; Tominaga; Nakagawa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2459 - 2462
反应条件
iron; ammonium chloride Heating;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 42, # 6 p. 2001 - 2017
反应条件
1: Br2, Fe / Heating 2: (nitration) 3: Fe, aq. NH4Cl / Heating View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 42, # 6 p. 2001 - 2017
反应条件
1: (nitration) 2: Fe, aq. NH4Cl / Heating View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 42, # 6 p. 2001 - 2017
反应条件
1: 65 percent / pyridine / 1 h / Heating 2: 86 percent / Lawesson's reagent; HMPA / 15 h / 100 °C 3: 87 percent / NaH / 1-methyl-pyrrolidin-2-one / 1 h / 140 °C 4: 54 percent / SnCl2*2H2O / ethanol / 2 h / Heating View Scheme
参考文献
Hutchinson; Chua; Browne; Trapani; Bradshaw; Westwell; Stevens
Journal of Medicinal Chemistry, 2001 , vol. 44, # 9 p. 1446 - 1455
反应条件
2: 86 percent / Raney nickel / ethanol / 3 h / Heating View Scheme
参考文献
Ishikawa; Uno; Miyamoto; Ueda; Tamaoka; Tominaga; Nakagawa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2459 - 2462
反应条件
(i) aq. NaNO2, H2SO4, (ii) /BRN= 4652394/, CuSO4, aq. NH3, CHCl3; Multistep reaction;
参考文献
Cervena; Sindelar; Kopicova; et al.
Collection of Czechoslovak Chemical Communications, 1977 , vol. 42, # 6 p. 2001 - 2017
反应条件
1: (i) aq. NaNO2, H2SO4, (ii) /BRN= 4652394/, CuSO4, aq. NH3, CHCl3 2: aq. H2SO4 / acetic acid / Heating View Scheme
参考文献
Cervena; Sindelar; Kopicova; et al.
Collection of Czechoslovak Chemical Communications, 1977 , vol. 42, # 6 p. 2001 - 2017
反应条件
1: 54 percent / N-chlorosuccinimide, NEt3 / CH2Cl2 / 1) -15 deg C, 2) reflux, 14 h 2: 80 percent / Raney Ni / ethanol / 1 h / Heating View Scheme
参考文献
Miyamoto; Ueda; Otsuka; Aki; Tamaoka; Tominaga; Nakagawa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2472 - 2475
反应条件
1: (i) aq. NaNO2, H2SO4, (ii) /BRN= 4652394/, CuSO4, aq. NH3, CHCl3
2: methanol / Heating
3: aq. H2SO4 / acetic acid / Heating
View Scheme
参考文献
Cervena; Sindelar; Kopicova; et al.
Collection of Czechoslovak Chemical Communications, 1977 , vol. 42, # 6 p. 2001 - 2017
