1: 1-hydroxybut-2-yne With sodium hydride in DMF (N,N-dimethyl-formamide) 1.5 h; 2: (1-(methanesulfonyl)piperidin-4-yl)methyl methanesulfonate in DMF (N,N-dimethyl-formamide) T=20°C; 2 h;

1: 4-(but-2-ynyloxymethyl)-1-(methanesulphonyl)-piperidine With lithium hexamethyldisilazane in tetrahydrofuran T=-17°C; Wadsworth-Emmons Reaction; 0.5 h; 2: With diethyl chlorophosphate in tetrahydrofuran T=0°C; 0.833333 h; 3: acetaldehyde in tetrahydrofuran 15 h;