(2S)-1-甲氧基-3-苯基-2-丙胺合成路线 （共 19 条）
反应条件
ammonium chloride in tetrahydrofuran; 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran
参考文献
British Bio-Technology Limited
Patent: US5180723 A1, 1993 ;
反应条件
potassium hydride in tetrahydrofuran
1.) room temperature, overnight, 2.) 0 deg C, 1 h;
参考文献
Mizutani, Tadashi; Yagi, Shigeyuki; Honmaru, Atsushi; Murakami, Shinji; Furusyo, Masaru; Takagishi, Toru; Ogoshi, Hisanobu
Journal of Organic Chemistry, 1998 , vol. 63, # 24 p. 8769 - 8784
反应条件
1: 79 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating
2: 1) NaH / 1) THF, r.t., 10 h, 2) r.t., 3 h
View Scheme
参考文献
Matsui, Syuichi; Uejima, Akinori; Suzuki, Yoshinori; Tanaka, Kazuhiko
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 6 p. 701 - 704
反应条件
thiophenol in dichloromethane; N,N-dimethyl-formamide
T=20°C; 0.75 h;
参考文献
Stanetty, Christian; Blaukopf, Markus K.; Lachmann, Bodo; Noe, Christian R.
European Journal of Organic Chemistry, 2011 , # 17 p. 3126 - 3130
反应条件
potassium carbonate in water
参考文献
NEUROCHEM (INTERNATIONAL) LIMITED
Patent: WO2004/113275 A2, 2004 ;
Location in patent: Page 201 ;
反应条件
hydrogenchloride in 1,4-dioxane
T=100°C;
参考文献
Ma, Xiang; Song, Yuting; Liu, Hao; Chen, Ruijiao; Chen, Xiaochuan
Synlett, 2012 , # 4 p. 607 - 610
反应条件
hydrogenchloride in 1,4-dioxane
T=100°C;
参考文献
Ma, Xiang; Song, Yuting; Liu, Hao; Chen, Ruijiao; Chen, Xiaochuan
Synlett, 2012 , # 4 p. 607 - 610
反应条件
hydrazine in ethanol
3 h; Ambient temperature;
参考文献
Cazin, Jacques; Duflos, Jack; Dupas, Georges; Bourguignon, Jean; Queguiner, Guy
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 867 - 872
反应条件
1: 78 percent / NaBH4 / aq. ethanol / 1.) room temperature, 4 h, 2.) reflux, 6 h, 3.) room temperature, overnight
2: KH
View Scheme
参考文献
Meyers,A.I.; Williams,D.R.; Erickson,G.W.
Journal of the American Chemical Society, 1981 , vol. 103, p. 3081
反应条件
1: 1.912 g / benzene / Heating
2: sodium hydride / tetrahydrofuran / 1.) room temp., 1 h; 2.) 0 deg C, 16 h; 3.) room temp., 18 h
3: 788 mg / 10percent aq. hydrochloric acid / 2 h / Heating
View Scheme
参考文献
Hiroi, Kunio; Sato, Shuko
Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 6 p. 2331 - 2338
