1-苄基-3-乙基-6,7-二甲氧基异喹啉盐酸盐合成路线 （共 52 条）
反应条件
1: 70 percent / Bu4NF / tetrahydrofuran / 1 h / Ambient temperature 2: 1.) DMSO/oxalyl chloride, 2.) NEt3 / 1.) CH2Cl2, -78 deg C, 30 min, 2.) -78 deg C to 0 deg C 3: 70percent ButOOH, 10percent aq. NaOH / tetrahydrofuran / 0.5 h / 0 °C 4: 1.) KOH, 2.) Ph3P, diethyl azodicarboxylate / 1.) MeOH, 60 deg C, 3h, 2.) benzene, RT, 13h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 10 p. 2835 - 2840
反应条件
1: 68 percent / Bu4NF / tetrahydrofuran / 1 h / Ambient temperature 2: 1.) DMSO/oxalyl chloride, 2.) NEt3 / 1.) CH2Cl2, -78 deg C, 30 min, 2.) -78 deg C to 0 deg C 3: 70percent ButOOH, 10percent aq. NaOH / tetrahydrofuran / 0.5 h / 0 °C 4: 1.) KOH, 2.) Ph3P, diethyl azodicarboxylate / 1.) MeOH, 60 deg C, 3h, 2.) benzene, RT, 13h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 10 p. 2835 - 2840
反应条件
Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 106, # 22 p. 6717 - 6725
反应条件
1: 76 percent / aq. HCl / tetrahydrofuran / 3 h / 55 - 60 °C 2: 30 percent / CrO3, pyridine / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Zeitschrift fuer Naturforschung, B: Chemical Sciences, , vol. 50, # 10 p. 1537 - 1542
反应条件
1: 43 percent / NaBH4 / hexamethylphosphoric acid triamide / 24 h / 100 °C 2: 76 percent / aq. HCl / tetrahydrofuran / 3 h / 55 - 60 °C 3: 30 percent / CrO3, pyridine / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Zeitschrift fuer Naturforschung, B: Chemical Sciences, , vol. 50, # 10 p. 1537 - 1542
反应条件
1: 90 percent / p-TsOH / CH2Cl2 / 0.5 h / Ambient temperature 2: 2) aq. sodium acetate / 1) acetic anhydride, reflux, 140 deg C, 1.5 h; 2) H2O, 4 h, 10 deg C View Scheme
参考文献
Agricultural and Biological Chemistry, , vol. 51, # 3 p. 635 - 640
反应条件
potassium hydroxide; triphenylphosphine; diethylazodicarboxylate 1.) MeOH, 60 deg C, 3 h, 2.) THF, 20 deg C, 13 h; Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 31, # 7 p. 1237 - 1240
反应条件
copper(l) iodide; chloro-trimethyl-silane; tri-n-butyl-tin hydride; lithium iodide 1.) THF, -60 deg C, 10 min, 2.) up to 0 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 49, # 27 p. 5961 - 5968
反应条件
1: 770 mg / conc. H2SO4 / 0.25 h / Ambient temperature 2: 1.21 g / acetic anhydride, acetic acid / Heating 3: 1.) CuI, LiI, TMSCl, 2.) n-Bu3SnH / 1.) THF, -60 deg C, 10 min, 2.) up to 0 deg C, 30 min View Scheme
参考文献
Tetrahedron, , vol. 49, # 27 p. 5961 - 5968
反应条件
1: 0.9 g / PCC 2: 1.) NaCH2SOCH3 / 1.) THF, 0 deg C, 1 h, 2a.) DMF, -40 deg C, 2 h, 2b.) RT, overnight View Scheme
参考文献
Synthetic Communications, , vol. 20, # 9 p. 1299 - 1303
