3,3'-亚戊烯基-4-丁内酰胺合成路线 （共 23 条）
反应条件
1: With sodium hydroxide in water pH=12; 2: With hydrogen in water; toluene T=80 - 85°C; P=3750.38 - 7500.75 Torr; Inert atmosphere;
参考文献
HIKAL LIMITED; YERANDE, Swapnil, Gulabrao; THAKUR, Rajesh, Mataprasad; SHARMA, Sundarakrishna, S.; GANGOPADHYAY, Ashok, Kumar; RUPP, Helmut; KUBAVAT, Hitesh; NAGARAJAN, Kuppuswamy; SELVAN, Arul; NUNNA, Rambabu; JALAJAKSHI, Vivekananda, Induharappa
Patent: WO2013/190357 A1, 2013 ;
Location in patent: Page/Page column 24 ;
反应条件
1: With sodium hydrogencarbonate T=25°C; pH=7.4 - 7.5; 28 h; Enzymatic reaction; 2: With sodium hydroxide in water T=20°C; 3: With hydrogen in water T=80°C; P=7500.75 Torr; Inert atmosphere; ConcentrationTime;
参考文献
HIKAL LIMITED; YERANDE, Swapnil, Gulabrao; THAKUR, Rajesh, Mataprasad; SHARMA, Sundarakrishna, S.; GANGOPADHYAY, Ashok, Kumar; RUPP, Helmut; KUBAVAT, Hitesh; NAGARAJAN, Kuppuswamy; SELVAN, Arul; NUNNA, Rambabu; JALAJAKSHI, Vivekananda, Induharappa
Patent: WO2013/190357 A1, 2013 ;
Location in patent: Page/Page column 24-25 ;
反应条件
1: With sodium hydroxide; bromine in water T=-10 - 0°C; 1.25 - 2 h; 2: 1-carbamoyl-cyclohexanecarboxylic acid in water T=-10 - 98°C; 11 - 20 h;
参考文献
Hikal Ltd.; Kuppuswamy, Nagarajan; Hariharan, Sivaramakrishnan; Mariadas, Arulselvan
Patent: WO2004/46108 A1, 2004 ;
Location in patent: Page 9-12 ;
反应条件
1: With sodium hydroxide; sodium hypochlorite in water T=0 - 40°C; 3.5 h; 2: With hydrogenchloride in water T=100 - 105°C; pH=8.2 - 8.8; 3 h; Heating / reflux; Product distribution / selectivity;
参考文献
Zhejiang Chiral Medicine Chemicals Co., Ltd.
Patent: US2007/287861 A1, 2007 ;
Location in patent: Page/Page column 3-4 ;
反应条件
sodium hydroxide; carbon in water T=80 - 85°C; 2 h;
参考文献
WO2004/46085 A1, ;
Page 23-24 ;
反应条件
1: With ammonia in ethanol T=20°C; 48 h; 2: With hydrogen; acetic acid; palladium on activated carbon T=80 - 100°C; P=2844.39 Torr; 3 h; Product distribution / selectivity;
参考文献
US2005/148792 A1, ;
Page/Page column 4 ;
反应条件
in palladium monocarbide; ethanol
参考文献
Godecke Aktiengesellschaft
Patent: US5091567 A1, 1992 ;
反应条件
ammonium cerium(IV) nitrate in water; acetonitrile T=20°C;
参考文献
Bryans, Justin S.; Chessum, Nicola E.A.; Huther, Nathalie; Parsons, Andrew F.; Ghelfi, Franco
Tetrahedron, 2003 , vol. 59, # 33 p. 6221 - 6231
反应条件
hydrogen; acetic acid; palladium on activated carbon T=80°C; P=2585.81 Torr; 6 h; Product distribution / selectivity;
参考文献
US2005/148792 A1, ;
Page/Page column 4 ;
反应条件
nickel in water; isopropyl alcohol
