3-[4-(二甲基氨基甲基)苯基]-4-甲基-7-苯基-9-氧杂-4,8-二氮杂双环[4.3.0]壬-2,7,10-三烯-5-酮合成路线 （共 7 条）
反应条件
hydrogenchloride; dimethyl amine in dichloromethane; toluene
参考文献
Sandoz, Inc.
Patent: US4049813 A1, 1977 ;
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 1 h / -70 °C
1.2: tetrahydrofuran; hexane / -70 - 20 °C
2.1: HCl / tetrahydrofuran / 20 °C
View Scheme
参考文献
Hintermann, Samuel; Chiesi, Michele; von Krosigk, Ulrike; Mathe, Daniele; Felber, Richard; Hengerer, Bastian
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 193 - 196
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 1 h / -70 °C
1.2: tetrahydrofuran; hexane / -70 - 20 °C
2.1: HCl / tetrahydrofuran / 20 °C
View Scheme
参考文献
Hintermann, Samuel; Chiesi, Michele; von Krosigk, Ulrike; Mathe, Daniele; Felber, Richard; Hengerer, Bastian
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 193 - 196
反应条件
1.1: SOCl2 / 1,2-dichloro-ethane / 2 h / 80 °C
2.1: ethanol / 12 h / 0 - 20 °C
3.1: BuLi / tetrahydrofuran; hexane / 1 h / -70 °C
3.2: tetrahydrofuran; hexane / -70 - 20 °C
4.1: HCl / tetrahydrofuran / 20 °C
View Scheme
参考文献
Hintermann, Samuel; Chiesi, Michele; von Krosigk, Ulrike; Mathe, Daniele; Felber, Richard; Hengerer, Bastian
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 193 - 196
反应条件
1.1: ethanol / 12 h / 0 - 20 °C
2.1: BuLi / tetrahydrofuran; hexane / 1 h / -70 °C
2.2: tetrahydrofuran; hexane / -70 - 20 °C
3.1: HCl / tetrahydrofuran / 20 °C
View Scheme
参考文献
Hintermann, Samuel; Chiesi, Michele; von Krosigk, Ulrike; Mathe, Daniele; Felber, Richard; Hengerer, Bastian
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 193 - 196
反应条件
1.1: SOCl2; DMF / 1,2-dichloro-ethane / 80 °C
2.1: i-Pr2NEt / 1,2-dichloro-ethane / 0 - 20 °C
3.1: BuLi / tetrahydrofuran; hexane / 1 h / -70 °C
3.2: tetrahydrofuran; hexane / -70 - 20 °C
4.1: HCl / tetrahydrofuran / 20 °C
View Scheme
参考文献
Hintermann, Samuel; Chiesi, Michele; von Krosigk, Ulrike; Mathe, Daniele; Felber, Richard; Hengerer, Bastian
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 193 - 196
反应条件
1.1: i-Pr2NEt / 1,2-dichloro-ethane / 0 - 20 °C
2.1: BuLi / tetrahydrofuran; hexane / 1 h / -70 °C
2.2: tetrahydrofuran; hexane / -70 - 20 °C
3.1: HCl / tetrahydrofuran / 20 °C
View Scheme
参考文献
Hintermann, Samuel; Chiesi, Michele; von Krosigk, Ulrike; Mathe, Daniele; Felber, Richard; Hengerer, Bastian
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 1 p. 193 - 196
