反应条件
1: ethylidenemalonic acid diethyl ester With N,N'-dimethyl-N,N'-propyleneurea; n-butyllithium; N-ethyl-N,N-diisopropylamine in tetrahydrofuran
T=-78°C; Knoevenagel condensation; 0.75 h; Inert atmosphere;
2: methyl iodide T=-78 - 20°C; 1.5 h; Reflux;
参考文献
Okrasa, Krzysztof; Wilding, Matthew; Goodall, Mark; Micklefield, Jason; Levy, Colin; Leys, David; Baudendistel, Nina; Hauer, Bernhard
Angewandte Chemie, International Edition, 2009 , vol. 48, # 41 p. 7691 - 7694
