(R)-1-(3,4-二甲氧基苯基)-2-丙胺合成路线 （共 5 条）
参考文献
American Cyanamid Company
Patent: US5482971 A1, 1996 ;
US 5482971 A
反应条件
glucose dehydrogenase; (R)-alanine; D-glucose; nicotinamide adenine dinucleotide; lactate dehydrogenase in aq. phosphate buffer; dimethyl sulfoxide
T=30°C; pH=7; Enzymatic reaction; enantioselective reaction;
参考文献
Orden, Alejandro A.; Schrittwieser, Joerg H.; Resch, Verena; Mutti, Francesco G.; Kroutil, Wolfgang
Tetrahedron Asymmetry, 2013 , vol. 24, # 12 p. 744 - 749
反应条件
1: 98 percent / LiBH4
2: 86 percent / triethylamine
4: H2 / Pd/C
View Scheme
参考文献
Bloom, Jonathan D.; Dutia, Minu D.; Johnson, Bernard D.; Wissner, Allan; Burns, Michael G.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 3081 - 3084
参考文献
Schrecker
Journal of Organic Chemistry, 1957 , vol. 22, p. 33
反应条件
in diethyl ether; ethanol
参考文献
Pratesi,P. et al.
Farmaco, Edizione Scientifica, 1964 , vol. 19, p. 529 - 536
