Marsilje, Thomas H.; Hedrick, Michael P.; Desharnais, Joel; Tavassoli, Ali; Zhang, Yan; Wilson, Ian A.; Benkovic, Stephen J.; Boger, Dale L.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 20 p. 4487 - 4501
1: in N,N-dimethyl-formamide
T=25°C; 0.75 h;
2: With potassium carbonate in N,N-dimethyl-formamide
18 h;
参考文献
Marsilje, Thomas H.; Hedrick, Michael P.; Desharnais, Joel; Tavassoli, Ali; Zhang, Yan; Wilson, Ian A.; Benkovic, Stephen J.; Boger, Dale L.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 20 p. 4487 - 4501
1.1: dimethylformamide / 0.75 h / 25 °C
1.2: 68 percent / K2CO3 / dimethylformamide / 18 h
2.1: 67 percent / K2CO3 / dimethylformamide / 1 h / 70 °C
3.1: 57 percent / sodium methoxide / methanol / 1 h / 25 °C
4.1: 54 percent / BBr3 / CH2Cl2 / 1 h / 0 °C
View Scheme
参考文献
Marsilje, Thomas H.; Hedrick, Michael P.; Desharnais, Joel; Tavassoli, Ali; Zhang, Yan; Wilson, Ian A.; Benkovic, Stephen J.; Boger, Dale L.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 20 p. 4487 - 4501
