copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=22 - 24°C;

1: 59 percent / LiOH*H2O / methanol / 1.5 h / 22 - 24 °C 2: 76 percent / DMAP; Et3N / pyridine / 3.5 h / 22 - 24 °C 3: pyridine / 2.5 h / 22 - 24 °C 4: 0.296 g / CF3CO2H / CH2Cl2 / 0.5 h / 22 - 24 °C View Scheme

lithium hydroxide in methanol T=22 - 24°C; 1.5 h;