5-乙基-4-(1-甲氧基-2-戊烷基)-1H-吡唑-3-胺合成路线 （共 3 条）
反应条件
hydrazine hydrate; acetic acid in toluene
Heating;
参考文献
Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4093 - 4102
反应条件
1.1: 68 percent / H2 / Pd/C / methanol; propan-2-ol / -78 - 20 °C
2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
2.2: 87 percent / tetrahydrofuran; hexane / -78 - 20 °C
3.1: 72 percent / hydrazine hydrate; acetic acid / toluene / Heating
View Scheme
参考文献
Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4093 - 4102
反应条件
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 87 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 72 percent / hydrazine hydrate; acetic acid / toluene / Heating
View Scheme
参考文献
Gilligan, Paul J.; Folmer, Beverly K.; Hartz, Richard A.; Koch, Stephanie; Nanda, Kausik K.; Andreuski, Stephen; Fitzgerald, Lawrence; Miller, Keith; Marshall, William J.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4093 - 4102
