2,6-二氯-4-甲氧基苯胺合成路线 (共 21 条)
反应条件
1: KNO2; sulfuric acid; sodium hydroxide / water / 2 h / -3 - 0 °C 2: chloro-trimethyl-silane / diethyl ether / 1 h / -5 - 0 °C View Scheme
参考文献
Synthesis, , # 7 p. 1045 - 1054
反应条件
hydrogenchloride T=20 - 30°C; hydrochlorination;
参考文献
Russian Journal of Organic Chemistry, , vol. 32, # 8 p. 1154 - 1159
反应条件
hydrogenchloride; tin
参考文献
Journal of the Chemical Society, , p. 2218
Journal of the Chemical Society, , p. 331
参考文献
Journal of the Chemical Society, , p. 2218
Journal of the Chemical Society, , p. 331
Journal of the Chemical Society, , p. 543
Journal of the Chemical Society, , p. 628
参考文献
Chemische Berichte, , vol. 8, p. 897
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, , vol. <6>8, p. 399
Chem. Zentralbl., , vol. 100, # I p. 1441
反应条件
1: 82 percent / K2CO3; CuI; Cu / toluene / 48 h / Heating 2: 81 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 1 h / 20 °C 3: 70 percent / aq. NaOH / ethanol / 12 h / Heating View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
sulfuric acid in acetic acid T=20°C; Acetylation; 2 h;
参考文献
Waterhouse, Ian
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 11 p. 1075 - 1083
参考文献
Bort, Roque; MacE, Katherine; Boobis, Alan; Gomez-Lechon, Maria-Jose.; Pfeifer, Andrea; Castell, Jose
Biochemical Pharmacology, 1999 , vol. 58, # 5 p. 787 - 796
反应条件
1: 82 percent / K2CO3; CuI; Cu / toluene / 48 h / Heating
2: 81 percent / BBr3 / CH2Cl2; 1,2-dichloro-ethane / 1 h / 20 °C
View Scheme
参考文献
Kenny, Jane R.; Maggs, James L.; Meng, Xiaoli; Sinnott, Deborah; Clarke, Stephen E.; Park, B. Kevin; Stachulski, Andrew V.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2816 - 2825
反应条件
1: KOH
2: oxalylchloride
3: P/HI
4: NaOH
View Scheme
参考文献
Bort, Roque; MacE, Katherine; Boobis, Alan; Gomez-Lechon, Maria-Jose.; Pfeifer, Andrea; Castell, Jose
Biochemical Pharmacology, 1999 , vol. 58, # 5 p. 787 - 796