2-乙基-2-苯基甘氨酸乙酯合成路线 （共 5 条）
反应条件
triethylamine in tetrahydrofuran
Dehydrochlorination; 0.333333 h;
参考文献
Martin, Arnaud; Figadere, Bruno; Saivin, Sylvie; Houin, Georges; Chomard, Jean Marie; Cahiez, Gerard
Arzneimittel-Forschung/Drug Research, 2000 , vol. 50, # 6 p. 544 - 549
反应条件
1: 93 percent / MgSO4; Et3N / CH2Cl2 / 17 h / 20 °C
2: 85 percent / NaH; CuCl2 / tetrahydrofuran / 18 h / 20 °C
3: 99 percent / HCl; Et2O; H2O / 24 h / 20 °C
4: 95 percent / Et3N / tetrahydrofuran / 0.33 h
View Scheme
参考文献
Martin, Arnaud; Figadere, Bruno; Saivin, Sylvie; Houin, Georges; Chomard, Jean Marie; Cahiez, Gerard
Arzneimittel-Forschung/Drug Research, 2000 , vol. 50, # 6 p. 544 - 549
反应条件
1: 85 percent / NaH; CuCl2 / tetrahydrofuran / 18 h / 20 °C
2: 99 percent / HCl; Et2O; H2O / 24 h / 20 °C
3: 95 percent / Et3N / tetrahydrofuran / 0.33 h
View Scheme
参考文献
Martin, Arnaud; Figadere, Bruno; Saivin, Sylvie; Houin, Georges; Chomard, Jean Marie; Cahiez, Gerard
Arzneimittel-Forschung/Drug Research, 2000 , vol. 50, # 6 p. 544 - 549
反应条件
1: 98.9 percent / SOCl2 / 5 h / Heating
2: 93 percent / MgSO4; Et3N / CH2Cl2 / 17 h / 20 °C
3: 85 percent / NaH; CuCl2 / tetrahydrofuran / 18 h / 20 °C
4: 99 percent / HCl; Et2O; H2O / 24 h / 20 °C
5: 95 percent / Et3N / tetrahydrofuran / 0.33 h
View Scheme
参考文献
Martin, Arnaud; Figadere, Bruno; Saivin, Sylvie; Houin, Georges; Chomard, Jean Marie; Cahiez, Gerard
Arzneimittel-Forschung/Drug Research, 2000 , vol. 50, # 6 p. 544 - 549
反应条件
1: 99 percent / Ac2O / 15 h / 20 °C
2: 97.9 percent / LiAlH4 / tetrahydrofuran / 8 h / Heating
View Scheme
参考文献
Martin, Arnaud; Figadere, Bruno; Saivin, Sylvie; Houin, Georges; Chomard, Jean Marie; Cahiez, Gerard
Arzneimittel-Forschung/Drug Research, 2000 , vol. 50, # 6 p. 544 - 549
