2-羟甲基-1,4-丁二醇合成路线 （共 13 条）
反应条件
1: p-toluenesulfonic acid / tetrahydrofuran 2: CBr4; PPh3 / tetrahydrofuran / 0 °C 3: K2CO3 / dimethylformamide 4: HCl View Scheme
参考文献
Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938
反应条件
1: 57 percent / p-TsOH*H2O / tetrahydrofuran / 19 h / 20 °C 2: 100 percent / CBr4; Ph3P / dimethylformamide / 2 h / 0 °C 3: 54 percent / K2CO3 / dimethylformamide / 5 h / 20 °C 4: 80 percent / aq. HCl / 2 h / Heating 5: 53 percent / 4-dimethylaminopyridine; Et3N / dimethylformamide / 6 h / 50 - 60 °C 6: 29 percent / pyridine / 21 h / 20 °C View Scheme
参考文献
Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938
反应条件
1: p-toluenesulfonic acid / tetrahydrofuran 2: CBr4; PPh3 / tetrahydrofuran / 0 °C View Scheme
参考文献
Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938
反应条件
toluene-4-sulfonic acid in tetrahydrofuran T=20°C; 4 h;
参考文献
You, Hyun; Youn, Hyung-Seop; Im, Isak; Bae, Man-Ho; Lee, Sang-Kook; Ko, Hyojin; Eom, Soo Hyun; Kim, Yong-Chul
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1153 - 1164
反应条件
toluene-4-sulfonic acid in tetrahydrofuran T=20°C; 1 h;
参考文献
ALT SOLUTIONS, INC.
Patent: WO2007/106561 A2, 2007 ;
Location in patent: Page/Page column 68-69 ;
反应条件
toluene-4-sulfonic acid T=20°C; 15 h;
参考文献
Eisai Co., Ltd.
Patent: US2007/10542 A1, 2007 ;
Location in patent: Page/Page column 58-59 ;
反应条件
1: 41 percent / p-TsOH*H2O / tetrahydrofuran / 0.5 h / Ambient temperature 2: 87 percent / CBr4, PPh3 / dimethylformamide / 0.5 h / 0 °C 3: 64 percent / K2CO3 / dimethylformamide / 5 h / Ambient temperature 4: cyclohexene / 10percent Pd/C / ethanol / Heating 5: aq. HCl / ethanol; cyclohexene; methanol / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 9 p. 1636 - 1642
反应条件
sulfuric acid; hydrogen bromide Heating;
参考文献
Pascal, Robert A.; Winans, Charles G.; Van Engen, Donna
Journal of the American Chemical Society, 1989 , vol. 111, # 8 p. 3007 - 3010
反应条件
1: p-toluenesulfonic acid / tetrahydrofuran
2: CBr4; PPh3 / tetrahydrofuran / 0 °C
3: K2CO3 / dimethylformamide
View Scheme
参考文献
Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938
反应条件
1: 41 percent / p-TsOH*H2O / tetrahydrofuran / 0.5 h / Ambient temperature
2: 87 percent / CBr4, PPh3 / dimethylformamide / 0.5 h / 0 °C
3: 64 percent / K2CO3 / dimethylformamide / 5 h / Ambient temperature
5: aq. HCl / Ambient temperature
View Scheme
参考文献
Harnden, Michael R.; Jarvest, Richard L.; Bacon, Teresa H.; Boyd, Malcolm R.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1636 - 1642
