3-甲氧基-4-甲基苯乙腈合成路线 （共 11 条）
反应条件
1: aq. NaOH 2: LiAlH4 3: SOCl2 4: dimethylformamide View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 42, # 7 p. 2240 - 2245
反应条件
1: LiAlH4 2: SOCl2 3: dimethylformamide View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 42, # 7 p. 2240 - 2245
反应条件
1: SOCl2 2: dimethylformamide View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 42, # 7 p. 2240 - 2245
反应条件
1: 87 percent / aq. potassium hydroxide (33percent w/w) 2: 98.7 percent / sodium borohydride / methanol 3: 1.) thionyl chloride, 2.) sodium iodide, H2O / 1.) benzene, 2.5 h, 2.) ethyl methyl ketone, reflux, 3 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1607 - 1613
反应条件
1: 98.7 percent / sodium borohydride / methanol 2: 1.) thionyl chloride, 2.) sodium iodide, H2O / 1.) benzene, 2.5 h, 2.) ethyl methyl ketone, reflux, 3 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1607 - 1613
反应条件
in N,N-dimethyl-formamide
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 42, # 7 p. 2240 - 2245
反应条件
thionyl chloride; water; sodium iodide 1.) benzene, 2.5 h, 2.) ethyl methyl ketone, reflux, 3 h; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1607 - 1613
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal in ethanol; water Inert atmosphere;
参考文献
ARENA PHARMACEUTICALS, INC.
Patent: WO2009/105206 A1, 2009 ;
Location in patent: Page/Page column 85 ;
WO 2009/105206 A1
反应条件
sodium hydroxide; water in ethanol 20 h; Heating / reflux;
参考文献
WELLSTAT THERAPEUTICS CORPORATION; SHARMA, Shalini; O'NEIL, James, Dennen; VON BORSTEL, Reid, W.; ARUDCHANDRAN, Ramchandran
Patent: WO2011/46800 A1, 2011 ;
Location in patent: Page/Page column 84 ;
WO 2011/046800 A1
反应条件
1: 65 percent / sodum acetate, bromine / CHCl3 / 1 h / Ambient temperature
2: 98.4 percent / 0.85N methanolic potassium hydroxide, H2O / 36 h / Heating
View Scheme
参考文献
Kametani, Tetsuji; Kigawa, Yoshio; Nemoto, Hideo; Ihara, Masataka; Fukumoto, Keiichiro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1607 - 1613
