N-乙酰基-4-溴-3,5-二甲基苯胺合成路线 （共 8 条）
反应条件
sodium hydroxide in ethanol 6 h; Heating;
参考文献
Rodriguez, Gema; Albrecht, Martin; Schoenmaker, Jeroen; Ford, Alan; Lutz, Martin; Spek, Anthony L.; Van Koten, Gerard
Journal of the American Chemical Society, 2002 , vol. 124, # 18 p. 5127 - 5138
反应条件
tetra-n-butylammonium tribromide in methanol; dichloromethane
0.166667 h; Ambient temperature;
参考文献
Kajigaeshi, Shoji; Kakinami, Takaaki; Yamasaki, Hiromichi; Fujisaki, Shizuo; Okamoto, Tsuyoshi
Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 7 p. 2681 - 2683
反应条件
1: in acetic acid
2: With bromine in acetic acid
cooling; Further stages.;
参考文献
Rodriguez, Gema; Albrecht, Martin; Schoenmaker, Jeroen; Ford, Alan; Lutz, Martin; Spek, Anthony L.; Van Koten, Gerard
Journal of the American Chemical Society, 2002 , vol. 124, # 18 p. 5127 - 5138
反应条件
in dichloromethane
T=0 - 20°C;
参考文献
Sung, Moo Je; Coppola, Gary Mark; Yoon, Taeyoung; Gilmore, Thomas A.
Patent: US2011/46133 A1, 2011 ;
Location in patent: Page/Page column 60 ;
反应条件
peracetic acid; sulfuric acid; potassium bromide; sodium tungstate in acetic anhydride; acetic acid
1 h;
参考文献
Medina, Inmaculada C. Rodriguez; Hanson, James R.
Journal of Chemical Research, Synopses, 2003 , # 7 p. 428 - 429
反应条件
1.1: hydrogen / palladium 10 on activated carbon / methanol / 16 h / 20 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.58 h / -78 - -40 °C
2.2: 2.5 h / -78 °C
2.3: 2.5 h / -78 - 0 °C
3.1: dichloromethane / 0 - 20 °C
View Scheme
参考文献
Sung, Moo Je; Coppola, Gary Mark; Yoon, Taeyoung; Gilmore, Thomas A.
Patent: US2011/46133 A1, 2011 ;
反应条件
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.58 h / -78 - -40 °C
1.2: 2.5 h / -78 °C
1.3: 2.5 h / -78 - 0 °C
2.1: dichloromethane / 0 - 20 °C
View Scheme
参考文献
Sung, Moo Je; Coppola, Gary Mark; Yoon, Taeyoung; Gilmore, Thomas A.
Patent: US2011/46133 A1, 2011 ;
反应条件
1.1: 80 percent / aq. NaOH / ethanol / 6 h / Heating
2.1: conc. HCl; NaNO2 / H2O / 0.5 h / cooling
2.2: KI / H2O / 0.75 h / Heating
View Scheme
参考文献
Rodriguez, Gema; Albrecht, Martin; Schoenmaker, Jeroen; Ford, Alan; Lutz, Martin; Spek, Anthony L.; Van Koten, Gerard
Journal of the American Chemical Society, 2002 , vol. 124, # 18 p. 5127 - 5138
