4-氯-2-吡啶-4-喹唑啉合成路线 （共 4 条）
反应条件
trichlorophosphate
12 h; Heating / reflux;
参考文献
REDDY US THERAPEUTICS, INC.; PAL, Manojit; KHANNA, Ish; SUBRAMANIAN, Venkataraman; PADAKANTI, Srinivas; PILLARISETTI, Sivaram
Patent: WO2006/58201 A2, 2006 ;
Location in patent: Page/Page column 117-118 ;
反应条件
1: Et3N / tetrahydrofuran; CH2Cl2 / 6 h / 23 °C
2: NaOMe / toluene / 18 h / Heating
3: 1.) N,N-dimethylaniline, 2.) POCl3 / 1.) C6H6, reflux, 30 min, 2.) C6H6, reflux, 6 h
View Scheme
参考文献
Lee; Konishi; Yu; Miskowski; Riviello; Macina; Frierson; Kondo; Sugitani; Sircar; Blazejewski
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3547 - 3557
反应条件
1: Et3N / tetrahydrofuran; CH2Cl2 / 6 h / 23 °C
2: NaOMe / toluene / 18 h / Heating
3: 1.) N,N-dimethylaniline, 2.) POCl3 / 1.) C6H6, reflux, 30 min, 2.) C6H6, reflux, 6 h
View Scheme
参考文献
Lee; Konishi; Yu; Miskowski; Riviello; Macina; Frierson; Kondo; Sugitani; Sircar; Blazejewski
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3547 - 3557
反应条件
1: NaOMe / toluene / 18 h / Heating
2: 1.) N,N-dimethylaniline, 2.) POCl3 / 1.) C6H6, reflux, 30 min, 2.) C6H6, reflux, 6 h
View Scheme
参考文献
Lee; Konishi; Yu; Miskowski; Riviello; Macina; Frierson; Kondo; Sugitani; Sircar; Blazejewski
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3547 - 3557
