3-氨基-1H-噻吩[3,2-C]吡唑-5-羧酸甲酯合成路线 (共 3 条)
反应条件
1: With hydrogenchloride; sodium nitrite in water 1.5 h; 2: With tin(ll) chloride in water T=5°C; 3 h;
参考文献
PHARMACIA ITALIA S.P.A.
Patent: WO2004/7504 A1, 2004 ;
Location in patent: Page 38-39 ;
WO 2004/007504 A1
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 1.5 h; 2: With hydrogenchloride; tin(ll) chloride in water T=5°C; 3 h; 3: With sodium hydroxide in water T=0°C; Product distribution / selectivity;
参考文献
Pharmacia Italia S.p.A.
Patent: US2006/160874 A1, 2006 ;
Location in patent: Page/Page column 15 ;
US 20060160874 A1
反应条件
1: With sulfuric acid 24 h; Heating / reflux; 2: With triethylamine in water T=4°C; pH=7 - 8; 18 h; Product distribution / selectivity;
参考文献
US2006/160874 A1, ;
Page/Page column 23 ;
US 20060160874 A1