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结构式
乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
648425-41-6
合成路线
(共 5 条)
867-13-0
膦酰乙酸三乙酯
+
99-02-5
间氯苯乙酮
→
反应条件
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in toluene T=4°C; 0.5 h; 2: methyl (3-chlorophenyl)-ketone in toluene T=4 - 20°C; Horner-Emmons condensation;
参考文献
Pinna, Gerard Aime; Cignarella, Giorgio; Ruiu, Stefania; Loriga, Giovanni; Murineddu, Gabriele; Villa, Stefania; Grella, Giuseppe Enrico; Cossu, Gregorio; Fratta, Walter
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4015 - 4026
867-13-0
膦酰乙酸三乙酯
+
99-02-5
间氯苯乙酮
→
反应条件
648425-41-6
反应条件
1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride in tetrahydrofuran; mineral oil T=0 - 20°C; Inert atmosphere; 2: methyl (3-chlorophenyl)-ketone in tetrahydrofuran; mineral oil T=20°C; Inert atmosphere;
参考文献
Shen, Li-Tao; Shao, Pan-Lin; Ye, Song
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 11-12 p. 1943 - 1948
648425-41-6
→
反应条件
648425-33-6
反应条件
1: 92 percent / diisobutylaluminum hydride / toluene / 1 h / -5 - 20 °C 2: 76 percent / methanesulfonyl chloride; Et3N / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Pinna, Gerard Aime; Cignarella, Giorgio; Ruiu, Stefania; Loriga, Giovanni; Murineddu, Gabriele; Villa, Stefania; Grella, Giuseppe Enrico; Cossu, Gregorio; Fratta, Walter
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4015 - 4026
648425-41-6
→
反应条件
648425-38-1
反应条件
diisobutylaluminium hydride in toluene T=-5 - 20°C; 1 h;
参考文献
Pinna, Gerard Aime; Cignarella, Giorgio; Ruiu, Stefania; Loriga, Giovanni; Murineddu, Gabriele; Villa, Stefania; Grella, Giuseppe Enrico; Cossu, Gregorio; Fratta, Walter
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4015 - 4026
648425-41-6
→
反应条件
7394-51-6
反应条件
water; potassium hydroxide T=100°C; Inert atmosphere;
参考文献
Shen, Li-Tao; Shao, Pan-Lin; Ye, Song
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 11-12 p. 1943 - 1948