反应条件
1.1: Mg / tetrahydrofuran / 2 h / 0 - 20 °C
1.2: tetrahydrofuran / 12 h / Heating
2.1: 6.51 g / NBS; AIBN / benzene / 24 h / 80 °C
3.1: 91 percent / AgOAc; H2O / ethanol; acetone / 24 h
4.1: 99 percent / DIBALH / CH2Cl2; toluene / 1.17 h / -78 - 0 °C
5.1: 96 percent / saccharin / CH2Cl2 / 24 h / 40 °C
View Scheme
参考文献
Huckins, John R.; Rychnovsky, Scott D.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10135 - 10145
