5-(1,3-二氧代lan-2-基)苯并呋喃合成路线 （共 4 条）
反应条件
tetra-n-butylammonium tribromide; trimethyl orthoformate
T=20°C;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2004/7491 A1, 2004 ;
Location in patent: Page 78 ;
反应条件
1: With n-butyllithium in tetrahydrofuran
T=25°C; 0.5 h;
2: With N-chloro-succinimide in tetrahydrofuran
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2004/7491 A1, 2004 ;
Location in patent: Page 79 ;
反应条件
1: 5-[1,3]dioxolan-2-yl-benzofuran With n-butyllithium in tetrahydrofuran
T=25°C; 0.5 h;
2: methyl iodide in tetrahydrofuran
T=20°C;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2004/7491 A1, 2004 ;
Location in patent: Page 81 ;
反应条件
1: With n-butyllithium in tetrahydrofuran
T=25°C; 0.5 h;
2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran
T=-78 - 20°C;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2004/7491 A1, 2004 ;
Location in patent: Page 83 ;
