1.1: 98 percent / t-BuOK / tetrahydrofuran / 0.67 h / 70 °C 2.1: EtMgBr / tetrahydrofuran / -78 - 20 °C 2.2: CuI / tetrahydrofuran / 0.17 h / 20 °C 2.3: 89 percent / tetrahydrofuran / 0.5 h / 20 °C 3.1: H2 / Pd(OH)2/C / methanol; ethyl acetate 4.1: cerium(IV) ammonium nitrate / acetonitrile; H2O / 0.5 h / 0 °C 5.1: 4-(dimethylamino)pyridine; pyridine / 1 h / 20 °C View Scheme