2-氧代-4-苯基丁酸乙酯合成路线 （共 50 条）
反应条件
hydrogen; chiral Ru complex T=20°C; P=25857.4 Torr; 48 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 128, # 17 p. 5955 - 5965
反应条件
D-glucose T=30°C; pH=7.0; 12 h; aq. phosphate buffer; optical yield given as percent eeenantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 350, # 3 p. 426 - 430
反应条件
1: 58 percent / 10percent HCl, acetic acid / 3 h / 50 °C 2: 99 percent / ammonium formate, formate dehydrogenase, NAD+, buffer (pH 8.5) / 24 h / 30 °C / PheDH View Scheme
参考文献
Asano; Yamada; Kato; Yamaguchi; Hibino; Hirai; Kondo
Journal of Organic Chemistry, 1990 , vol. 55, # 21 p. 5567 - 5571
反应条件
triethylamine in tetrahydrofuran 3.5 h; Ambient temperature;
参考文献
Okonya; Johnson; Hoffman
Journal of Organic Chemistry, 1998 , vol. 63, # 18 p. 6409 - 6413
反应条件
4-methyl-morpholine in methanol; cyclohexane
参考文献
DeGussa Aktiengesellschaft
Patent: US5387696 A1, 1995 ;
反应条件
sodium ethanolate; sodium cyanoborohydride; sodium hydrogencarbonate in ethanol
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4462943 A1, 1984 ;
反应条件
1: 29 percent / H2, AcONa, AcOH, molecular sieves 3A / Raney Ni / ethanol 2: 93 percent / HCl / H2O / 4 h 3: 68 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / 1 h 4: 95 percent / HBr-AcOH 25percent / acetic acid / 0.17 h 5: 74 percent / NaHCO3, 7N HCl / ethyl acetate; H2O View Scheme
参考文献
Miyake; Itoh; Oka
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 7 p. 2852 - 2858
反应条件
sodium cyanoborohydride
参考文献
Ciba-Geigy Corporation
Patent: US4575503 A1, 1986 ;
Title/Abstract Full Text Show Details
Ciba-Geigy Corporation
Patent: US4410520 A1, 1983 ;
Title/Abstract Full Text Show Details
Ciba-Geigy Corporation
Patent: US4473575 A1, 1984 ;
反应条件
Bacillus subtilis; NADPH in aq. phosphate buffer T=30°C; 12 h;
参考文献
Su, Yuning; Ni, Ye; Wang, Junchao; Xu, Zhihao; Sun, Zhihao
Chinese Journal of Catalysis, 2012 , vol. 33, # 9-10 p. 1650 - 1660
反应条件
1: lithium hydroxide hydrate / ethanol / 1 h / Cooling with ice; Inert atmosphere 2: hydrogenchloride / water / 80 °C / pH 2 / Inert atmosphere 3: C52H50ClO4P2Ru(1+)*Cl(1-); hydrogen bromide; hydrogen / tetrahydrofuran; water / 12 h / Autoclave View Scheme
参考文献
Zhu, Lufeng; Chen, Houhe; Meng, Qinghua; Fan, Weizheng; Xie, Xiaomin; Zhang, Zhaoguo
Tetrahedron, 2011 , vol. 67, # 34 p. 6186 - 6190
