2-氧代-4-苯基丁酸乙酯合成路线 （共 50 条）
反应条件
1: 89 percent / aq. NaOH / 0 °C 2: 75 percent / dicyclohexylcarbodiimide / diethyl ether / 1.5 h / 20 °C View Scheme
参考文献
Dao, Duc Hai; Kawai, Yasushi; Hida, Kouichi; Bornes, Sander; Nakamura, Kaoru; Ohno, Atsuyoshi; Okamura, Mutsuo; Akasaka, Takeshi
Bulletin of the Chemical Society of Japan, 1998 , vol. 71, # 2 p. 425 - 432
反应条件
hydrogenchloride; sodium cyanoborohydride in methanol; dichloromethane; acetic acid; butanone
参考文献
Ciba-Geigy Corporation
Patent: US4575503 A1, 1986 ;
Title/Abstract Full Text Show Details
Ciba-Geigy Corporation
Patent: US4473575 A1, 1984 ;
反应条件
sodium cyanoborohydride in methanol; acetic acid Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1511 - 1516
反应条件
1: 29 percent / H2, AcONa, AcOH, molecular sieves 3A / Raney Ni / ethanol 2: 93 percent / HCl / H2O / 4 h 3: 67 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / 1 h 4: HCl / ethyl acetate 5: 53 percent / ethyl acetate; ethanol View Scheme
参考文献
Miyake; Itoh; Oka
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 7 p. 2852 - 2858
反应条件
sodium cyanoborohydride; triethylamine in ethanol; water
参考文献
Merck and Co. Inc.
Patent: US5670655 A1, 1997 ;
反应条件
nickel monoaluminide; silica gel in ethanol; methyl acetate; water; ethyl acetate
参考文献
Nicox, S.A.
Patent: US6218417 B1, 2001 ;
反应条件
nickel var. catalysts and reducing agents, diastereomeric ratio; Product distribution;
参考文献
Huffman, Mark A.; Reider, Paul J.
Tetrahedron Letters, 1999 , vol. 40, # 5 p. 831 - 834
反应条件
1: 29 percent / H2, AcONa, AcOH, molecular sieves 3A / Raney Ni / ethanol 2: 93 percent / HCl / H2O / 4 h 3: 67 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / 1 h 4: HCl / ethyl acetate View Scheme
参考文献
Miyake; Itoh; Oka
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 7 p. 2852 - 2858
反应条件
sodium hydroxide T=0°C; Hydrolysis;
参考文献
Dao, Duc Hai; Kawai, Yasushi; Hida, Kouichi; Bornes, Sander; Nakamura, Kaoru; Ohno, Atsuyoshi; Okamura, Mutsuo; Akasaka, Takeshi
Bulletin of the Chemical Society of Japan, 1998 , vol. 71, # 2 p. 425 - 432
反应条件
nickel var. catalysts and reducing agents, diastereomeric ratio; Product distribution;
参考文献
Journal of Organic Chemistry, , vol. 53, # 4 p. 836 - 844
