2-氧代-4-苯基丁酸乙酯合成路线 （共 50 条）
反应条件
1: With 1,3-propanedithiol copolymer; boron trifluoride diethyl etherate in chloroform T=0°C; 10 h; 2: With 2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in toluene T=105°C; 2.5 h;
参考文献
Bertini, Vincenzo; Lucchesini, Francesco; Pocci, Marco; Alfei, Silvana; De Munno, Angela
Synlett, 2003 , # 8 p. 1201 - 1203
反应条件
1: lithium hydroxide hydrate / ethanol / 1 h / Cooling with ice; Inert atmosphere 2: hydrogenchloride / water / 80 °C / pH 2 / Inert atmosphere 3: [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; hydrogen bromide; hydrogen / tetrahydrofuran; water / 20 h / 70 °C / 20686.5 Torr / Autoclave View Scheme
参考文献
Zhu, Lufeng; Chen, Houhe; Meng, Qinghua; Fan, Weizheng; Xie, Xiaomin; Zhang, Zhaoguo
Tetrahedron, 2011 , vol. 67, # 34 p. 6186 - 6190
反应条件
1: lithium hydroxide hydrate / ethanol / 1 h / Cooling with ice; Inert atmosphere 2: hydrogenchloride / water / 80 °C / pH 2 / Inert atmosphere 3: C52H50ClO4P2Ru(1+)*Cl(1-); hydrogen bromide; hydrogen / tetrahydrofuran; water / 12 h / Autoclave View Scheme
参考文献
Zhu, Lufeng; Chen, Houhe; Meng, Qinghua; Fan, Weizheng; Xie, Xiaomin; Zhang, Zhaoguo
Tetrahedron, 2011 , vol. 67, # 34 p. 6186 - 6190
反应条件
D-glucose T=30°C; pH=7.0; 12 h; aq. phosphate buffer; optical yield given as percent eeenantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 350, # 3 p. 426 - 430
反应条件
lt;RhTFAlt;Cygt;(AMPP)gt;2; hydrogen in toluene T=20°C; P=38000 Torr; 1.5 h; other glyoxalic acid derivatives, other rhodium catalysts; var. time and pressure; Product distribution;
参考文献
Tetrahedron Asymmetry, , vol. 8, # 7 p. 1083 - 1099
反应条件
hydrogen; chiral Ru complex T=20°C; P=25857.4 Torr; 72 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 128, # 17 p. 5955 - 5965
反应条件
1: 29 percent / H2, AcONa, AcOH, molecular sieves 3A / Raney Ni / ethanol
2: 93 percent / HCl / H2O / 4 h
View Scheme
参考文献
Miyake; Itoh; Oka
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 7 p. 2852 - 2858
反应条件
1: With hydrogenchloride in ethanol; water
T=20°C; Acidic conditions;
2: With potassium hydroxide in ethanol; water
2 h; Heating / reflux;
3: With hydrogenchloride in ethanol; water
pH=1;
参考文献
BAYER HEALTHCARE AG
Patent: WO2005/3118 A1, 2005 ;
Location in patent: Page/Page column 37 ;
反应条件
sodium cyanoborohydride in methanol; acetic acid
Ambient temperature;
参考文献
Watthey; Stanton; Desai; Babiarz; Finn
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1511 - 1516
反应条件
1: 89 percent / aq. NaOH / 0 °C
2: 75 percent / dicyclohexylcarbodiimide / diethyl ether / 1.5 h / 20 °C
3: Heating
View Scheme
参考文献
Dao, Duc Hai; Kawai, Yasushi; Hida, Kouichi; Bornes, Sander; Nakamura, Kaoru; Ohno, Atsuyoshi; Okamura, Mutsuo; Akasaka, Takeshi
Bulletin of the Chemical Society of Japan, 1998 , vol. 71, # 2 p. 425 - 432
