7-溴-2,3-二氢-1,8-萘啶-4(1h)-酮合成路线 （共 5 条）
反应条件
1: With methanesulfonic acid; phosphorous pentoxide
T=75°C; 2.5 h;
2: With sodium hydroxide in water
pH=12;
参考文献
CEPHALON, INC.
Patent: WO2007/130468 A2, 2007 ;
Location in patent: Page/Page column 190 ;
反应条件
hydrogenchloride in benzene
24 h; Ambient temperature;
参考文献
Da Settimo; Biagi; Primofiore; et al.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 6 p. 1225 - 1229
反应条件
sodium hydrogencarbonate; nickel in 1,4-dioxane
T=100°C;
参考文献
Saccomanni, Giuseppe; Badawneh, Muwaffag; Adinolfi, Barbara; Calderone, Vincenzo; Cavallini, Tiziana; Ferrarini, Pier Luigi; Greco, Rosamiria; Manera, Clementina; Testai, Lara
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 4921 - 4931
反应条件
1: 74.5 percent / NaHCO3 / Raney nickel / dioxane / 100 °C
2: 97 percent / N-bromosuccinimide / CHCl3 / 2 h / Heating
View Scheme
参考文献
Saccomanni, Giuseppe; Badawneh, Muwaffag; Adinolfi, Barbara; Calderone, Vincenzo; Cavallini, Tiziana; Ferrarini, Pier Luigi; Greco, Rosamiria; Manera, Clementina; Testai, Lara
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 4921 - 4931
反应条件
in methanol
Ambient temperature;
参考文献
Carboni; Da Settimo; Ferrarini; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 2 p. 159 - 164
