乙基咪唑[2,1-b]噻唑-6-羧酸合成路线 （共 4 条）
反应条件
in tetrahydrofuran T=25°C; 20 h;
参考文献
Kaizerman, Jacob A.; Gross, Matthew I.; Ge, Yigong; White, Sarah; Hu, Wenhao; Duan, Jian-Xin; Baird, Eldon E.; Johnson, Kirk W.; Tanaka, Richard D.; Moser, Heinz E.; Buerli, Roland W.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3914 - 3929
反应条件
in ethanol Cyclization; 9 h; Heating;
参考文献
Journal of Chemical Research, Miniprint, , # 7 p. 1750 - 1760
反应条件
potassium hydroxide in ethanol T=25°C; 1.33333 h;
参考文献
Kaizerman, Jacob A.; Gross, Matthew I.; Ge, Yigong; White, Sarah; Hu, Wenhao; Duan, Jian-Xin; Baird, Eldon E.; Johnson, Kirk W.; Tanaka, Richard D.; Moser, Heinz E.; Buerli, Roland W.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3914 - 3929
反应条件
1: 82 percent / hydrazine hydrate / H2O / 5 h / Heating 2: 89 percent / pyridine / 4 h / Ambient temperature 3: 46 percent / K2CO3 / ethane-1,2-diol / 0.08 h / 130 - 140 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 23, p. 385 - 390
