4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=20°C;
参考文献
Bennett, Christopher J.; Caldwell, Stuart T.; McPhail, Donald B.; Morrice, Philip C.; Duthie, Garry G.; Hartley, Richard C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2079 - 2098
1.1: tetrahydrofuran / 20 °C
2.1: 2,6-lutidine / CH2Cl2 / 2 h
2.2: Pd(PPh3)4; K3PO4; KBr / tetrahydrofuran; H2O / 2 h / 65 °C
3.1: 1.01 g / 4-(dimethylamino)pyridine; EDCI / CH2Cl2 / 20 °C
View Scheme
参考文献
Bennett, Christopher J.; Caldwell, Stuart T.; McPhail, Donald B.; Morrice, Philip C.; Duthie, Garry G.; Hartley, Richard C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2079 - 2098
1.1: 2,6-lutidine / CH2Cl2 / 2 h
1.2: Pd(PPh3)4; K3PO4; KBr / tetrahydrofuran; H2O / 2 h / 65 °C
2.1: 1.01 g / 4-(dimethylamino)pyridine; EDCI / CH2Cl2 / 20 °C
View Scheme
参考文献
Bennett, Christopher J.; Caldwell, Stuart T.; McPhail, Donald B.; Morrice, Philip C.; Duthie, Garry G.; Hartley, Richard C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2079 - 2098
1.1: zinc chloride; hydrogen chloride / diethyl ether / 2 h
1.2: 48 percent / H2O / 1 h / Heating
2.1: 2,6-lutidine / CH2Cl2 / 2 h
2.2: Pd(PPh3)4; K3PO4; KBr / tetrahydrofuran; H2O / 2 h / 65 °C
3.1: 1.01 g / 4-(dimethylamino)pyridine; EDCI / CH2Cl2 / 20 °C
View Scheme
参考文献
Bennett, Christopher J.; Caldwell, Stuart T.; McPhail, Donald B.; Morrice, Philip C.; Duthie, Garry G.; Hartley, Richard C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2079 - 2098
1: 88 percent / lithium hexamethyldisilylazide / tetrahydrofuran / 1 h / -20 °C
2: 69 percent / trimethylsilyl trifluoromethanesulfonate / CH2Cl2 / 1 h / 20 °C
View Scheme
参考文献
Bennett, Christopher J.; Caldwell, Stuart T.; McPhail, Donald B.; Morrice, Philip C.; Duthie, Garry G.; Hartley, Richard C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2079 - 2098
